Xiao
Chai Hu Tang and Hepatitis B
Xiao-Chai-Hu-Tang, a famous
traditional Chinese herbal formula originally recorded in "Shang Han
Lun", has been used to treat liver diseases especially chronic hepatitis
for thousands of years in China and Japan. It consists of seven medicinal herbs
(Bupleurum falcatum, Scutellaria baicalensis, Panax ginseng,
Zizyphus jujube, Pinellia ternate, Zingiber officinale,
and Glycyrrhiza glabra). Much pharmacological research has shown that
Xiao-Chai-Hu-Tang has potent anti-inflammation, anti-oxidation,
immunomodulation, hepatoprotective, anti-hepatic fibrosis, and antitumor
properties. Recently, a lot of basic or clinical studies have been conducted to
assess the beneficial effects and safety of Xiao-Chai-Hu-Tang for CHB treatment.
Chang et al. found that Xiao-Chai-Hu-Tang could inhibit the replication of
HBV DNA and decrease the expression of HBeAg in HepG2 2.2.15 cells. Tajiri et
al. found that Xiao-Chai-Hu-Tang could promote the clearance of HBeAg in children
with chronic HBV infection. Qin et al. gave a systematic review of
randomized trials on treatment of CHB using Xiao-Chai-Hu-Tang. Sixteen
randomized trials (involving 1,601 CHB patients) were included in this review.
The pooled results showed that Xiao-Chai-Hu-Tang combined with antiviral drugs
(e.g., lamivudine and IFN-α) was more effective in serum loss of
hepatitis B viral markers and in improving liver function compared to antiviral
drugs alone. Moreover, there were no adverse effects reported in the trials
regarding Xiao-Chai-Hu-Tang.
Excerpt
from Qi FH, Wang ZX, Cai PP, Zhao L, Gao JJ, Kokudo N, Li AY, Han JQ, Tang W. Traditional Chinese medicine and related active compounds: A review of
their role on hepatitis B virus infection. Drug Discov Ther. 2013 Dec;7(6):212-224.
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