Chinese Herb as Good
as RA Drug
A traditional Chinese herbal remedy used to relieve joint pain
and inflammation works as well as methotrexate, a standard drug treatment that
is frequently prescribed to control the symptoms of active rheumatoid arthritis
(RA), reveals research published online in the Annals of the Rheumatic
Diseases.
Furthermore, combining the herbal remedy with methotrexate — the
disease modifying drug (DMARD) most commonly used to treat RA — was more
effective than treatment with methotrexate alone, the findings showed.
Triptergium wilfordii Hook F, or TwHF, is used in traditional
Chinese medicine to treat joint pain, swelling, and inflammation, and is
already approved for the treatment of RA in China.
The research team randomly assigned 207 patients with active RA
to one of three treatment groups: methotrexate 12.5mg once a week; or TwHF 20mg
three times a day; or a combination of the two over a period of 24 weeks.
The researchers wanted to find out which of these approaches
would sufficiently alleviate symptoms to reach an ACR 50 response. This
indicates a 50 per cent improvement in the number of tender or swollen joints
and other criteria including pain, disability, and the doctor’s assessment of
disease severity.
Most (174; 84 per cent) of the participants completed the full
24 weeks of the trial. The proportion of patients achieving ACR 50 was almost
46.5 per cent in those treated with methotrexate alone; 55 per cent in those
treated with TwHF alone; and just under 77 per cent in those treated with both.
Similar clinically significant patterns of improvement in
disease activity and remission rates also occurred among the three treatment
groups.
There was little difference between the frequency or type of
side effects experienced in the different treatment groups, although the number
of women who developed irregular periods was slightly higher in those treated
with TwHF.
More than 300 compounds have been identified in TwHF, including
diterpenoids, which experimental research suggests can suppress genes
controlling inflammation and dampen down the immune response, the authors point
out.
And an extract of the root has recently been investigated for
its potential to treat automimmune diseases and some cancers, say the
researchers from Peking Union Medical College.
Source of the report is here.