Jing Qian Zhi Tong Fang and Dysmenorrhea
The
Chinese herbal formula Jing Qian Zhi Tong Fang (JQF) is considered to be an
effective prescription for the treatment of primary dysmenorrhea. JQF
originally came from Foshou San, which has been proven to treat cold retention
and blood pattern in gynecological diseases. Angelica is the main herb in JQF
and could regulate menstrual pain. Angelica oil (including 70% ligustilide) can
relieve uterine smooth muscle pain. Motherwort can regulate menstruation. Chuanxiong
was used in the clinical treatment of irregular menstruation, amenorrhea,
dysmenorrhea, and headache. And its main components ferulic acid, tetramethylpyrazine,
and ligustilide have an antispasmodic effect on smooth muscles and can lead to
uterine smooth muscle relaxation. Radix paeoniae Rubra is rich in glycosides,
which can heat and cool blood, heal bruises, and relieve pain.
A
study was conducted to investigate the clinical therapeutic effects of JQF and
the differences in serum sex hormone levels during the treatment of primary dysmenorrhea.
The study selected 30 healthy volunteers and 60 individuals with primary
dysmenorrhea. On the third day of the menstrual cycle, they used ELISA to
determine the levels of serum prolactin (PRL), follicle-stimulating hormone
(FSH), luteinizing hormone (LH), testosterone (TEST), progesterone (PROG), and
estradiol (E2) compared with normal levels and levels
in the JQF group, the Western medicine group receiving continuous treatment
during the first and third menstrual cycles, and the group followed up after
the drug was stopped. The researchers observed that after JQF treatment, the
levels of the following hormones changed significantly: PRL, LH, TEST, and E2 levels
decreased significantly and the PROG level increased significantly after
treatment. After treatment with Western medicine, the serum levels of FSH, LH,
PROG, and E2 showed no significant change. The study
concluded that the long-term effect of JQF treatment was better than that of Western
medicine. JQF treatment of primary dysmenorrhea is related to adjustment of
PRL, LH, TEST, and E2 hormone levels in the human body.
Na Dai, Ling Fang, Yu-bo Li, Yu-mingWang, Ju Yin, and Bao-chan Pu. Effect
of Jingqian Zhitong Fang on Serum Sex Hormone Levels in Women with Primary Dysmenorrhea. Evidence-Based Complementary and Alternative
Medicine, Volume 2014, Article ID 876431.
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