Yi Shen Hua Zhuo Tang for Alzheimer's Disease
To explore the efficacy of Chinese herbal
formula compared with donepezil 5mg/day in patients with mild Alzheimer's
disease (AD). Patients with mild AD meeting the criteria were randomized into Chinese
herbal formula Yishen Huazhuo decoction (YHD) group and donepezil hydrochloride
(DH) group during the 24-week trial. The outcomes were measured by ADAS-cog,
MMSE, ADL, and NPI with linear mixed-effect models. 144 patients were
randomized. The mean scores of ADAS-cog and MMSE in both YHD group and DH group
both improved at the end of the 24-week treatment period. The results also
revealed that YHD was better at improving the mean scores of ADAS-cog and MMSE
than DH. Linear mixed-effect models with repeated measures showed statistical
significance in time × group interaction effect of ADAS-cog and also in time × group
interaction effect of MMSE. The data showed YHD was superior to DH in improving
the scores and long term efficacy. Our study suggests that Chinese herbal
formula YHD is beneficial and effective for cognitive improvement in patients
with mild AD and the mechanism might be through reducing amyloid-β (Aβ) plaque
deposition in the hippocampus.
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