Long
Dan Xie Gan Tang and Hepatitis B
Long-Dan-Xie-Gan-Tang is a famous
Chinese herbal formula which also originally came from "Tai Ping Hui Min
He Ji Ju Fang". It was recorded to have inhibitive effects on inflammatory
diseases of the liver or gall bladder. There are ten medicinal herbs in
Long-Dan-Xie-Gan-Tang including Gentiana scabra, Scutellaria baicalensis, Gardenia
jasminoides, Alisma plantago, Plantago
asiatica, Akebia trifoliate, Rhemannia
glutinosa, Angelica sinensis, Bupleurum
chinense and Glycyrrhiza uralensis. Recently, much pharmacological research has shown that Long-Dan-Xie-Gan-Tang has potent anti-inflammation, anti-oxidation, immune modulation, anti-herpetic virus, and anti-HBV properties. It is reported that Long-Dan-Xie-Gan-Tang is the
most commonly prescribed Chinese herbal
formula for subjects with CHB in Taiwan. It has a hepatoprotective effect on CCl4-induced hepatic injury in rats with the level of serum ALT and AST decreased significantly after treatment with
Long-Dan-Xie-Gan-Tang. In addition, Long-Dan-Xie-Gan-Tang combined with IFN-α
could significantly
improve the negative conversion
rates of HBeAg in the
treatment of CHB.
Excerpt
from Qi FH, Wang ZX, Cai PP, Zhao L, Gao JJ, Kokudo N, Li AY, Han JQ, Tang W. Traditional Chinese medicine and related active compounds: A review of
their role on hepatitis B virus infection. Drug Discov Ther. 2013 Dec;7(6):212-224.
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