Anti-inflammatory Mechanism of
Acupuncture
Previous anti-inflammatory
strategies against sepsis, a leading cause of death in hospitals, had limited
efficacy in clinical trials, in part because they targeted single cytokines and
the experimental models failed to mimic clinical settings. Neuronal networks
represent physiological mechanisms, selected by evolution to control
inflammation, that can be exploited for the treatment of inflammatory and
infectious disorders. Here, we report that sciatic nerve activation with electroacupuncture
controls systemic inflammation and rescues mice from polymicrobial peritonitis.
Electroacupuncture at the sciatic nerve controls systemic inflammation by
inducing vagal activation of aromatic L-amino acid decarboxylase, leading to
the production of dopamine in the adrenal medulla. Experimental models with adrenolectomized
mice mimic clinical adrenal insufficiency, increase the susceptibility to
sepsis and prevent the anti-inflammatory effects of electroacupuncture. Dopamine
inhibits cytokine production via dopamine type 1 (D1) receptors. D1 receptor
agonists suppress systemic inflammation and rescue mice with adrenal
insufficiency from polymicrobial peritonitis. Our results suggest a new
anti-inflammatory mechanism mediated by the sciatic and vagus nerves that modulates
the production of catecholamines in the adrenal glands. From a pharmacological
perspective, the effects of selective dopamine agonists mimic the
anti-inflammatory effects of electroacupuncture and can provide therapeutic
advantages to control inflammation in infectious and inflammatory disorders.
Torres-Rosas R, Yehia G,
Peña G,
Mishra P,
del Rocio
Thompson-Bonilla M, Moreno-Eutimio
MA, Arriaga-Pizano
LA, Isibasi A,
Ulloa L.
Dopamine mediates
vagal modulation of the immune system by electroacupuncture. Nat Med. 2014 Mar;20(3):291-5.